Keywords: BAIAP2-ROS1 fusion, advanced lung adenocarcinoma, sensitive to crizotinib, next-generation sequencing The good response to crizotinib therapy emphasizes the importance of DNA-based and RNA-based NGS in rare fusion identification in clinical practice. The patient subsequently received crizotinib and showed significant tumor reduction until 17 months, who got benefit from targeted therapy.Ĭonclusion: This study discovered a novel BAIAP2-ROS1 rearrangement it provides more knowledge of ROS1 fusion in clinical personalized treatment. A complete kinase domain in ROS1 fusion was preserved. Rearrangement consisted of BAIAP2 in exon1-exon13 of chr17: q23 and ROS1 in exon35-exon43 of chr6: q22, which were further confirmed by RNA-based NGS methodology. Results: Using DNA-targeted NGS method, we identified a novel BAIAP2-ROS1 fusion in a 71-year-old non-smoking female patient with stage IVB lung adenocarcinoma. RNA fusion panel based on hybrid capture sequencing was performed to verify gene fusions from total RNA which isolated from formalin fixed paraffin-embedded (FFPE) tissue blocks. Materials and Methods: Deep-coverage targeting solid tumor 31 cancer-related genes panel was used to capture DNA-based NGS information to detect gene fusion. Therefore, it is important to accurately identify the type of ROS1 rearrangement in NSCLC for clinical treatment selection. Objective: Previous studies have shown that fusion partners have a potential role in influencing different tumorigenic abilities of ROS1 fusion variants, as well as potential differential responses to crizotinib. *These authors contributed equally to this workĬorrespondence: Qiqi Tian Wendy Wu, Email Web browser.YunYu Lin, 1, * Yan Lei, 2, * LinWei Li, 2 Xiaoxing Su, 2 Qiqi Tian, 1 Wendy Wu 2ġRespiratory Medicine, NingHai First Hospital, NingBo, 315600, People’s Republic of China 2Berry Oncology Institutes, Berry Oncology Corporation, Fuzhou, 350200, People’s Republic of China The site is designed to comply to relevant W3C standards, and so should be usable in any standards-compliant Proper support for Unicode (including so-called 'surrogates') is also needed, which may cause additional problems To confirm whether your system properly supports these characters, please In addition, because the ancient texts on this site incorporate many now obsolete and rarely-used characters, you will need to installĪ Unicode font which provides support for such characters (often referred to as CJK Extensions A through D).Ī suitable font is the freely downloadable " Hanazono" font " Han Nom" also includes many (though not all) of the required characters. In order to view the Chinese text on this site, you will need to have a Chinese font and compatible web browser installed. Please note that only major technical updates are listed here for content updates and recently added texts (which occur daily and hourly), please log in and refer to the Wiki Recently Updated sections. Previous technical updates are listed in the " Latest updates" forum. Many new characters belong to "CJK Extension E" - you can confirm system support for these from the Font Test Page.
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